Parsaclisib HCl ( INCB50465 HCl; INCB-50465; INCB 50465; INCB050465 HCl; INCB-050465; INCB 050465 )

Catalog No. M23900 CAS No. 1995889-48-9

Parsaclisib HCl is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.

Purity : >98% (HPLC)

COA

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HNMR

HPLC

MSDS

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Biological Information

Product Name

Parsaclisib HCl
Note

Research use only, not for human use.
Brief Description

Parsaclisib HCl is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.
Description

Parsaclisib HCl is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.
Synonyms

INCB50465 HCl; INCB-50465; INCB 50465; INCB050465 HCl; INCB-050465; INCB 050465
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3Kδ
Research Area

——
Indication

——

Chemical Information

CAS Number

1995889-48-9
Formula Weight

469.3
Molecular Formula

C20H23Cl2FN6O2
Purity

>98% (HPLC)
Solubility

DMSO:90 mg/mL(191.76 mM);Water:Insoluble
SMILES

O=C1NC[C@@H](C2=C(F)C(Cl)=CC([C@@H](N3N=C(C)C4=C(N)N=CN=C43)C)=C2OCC)C1.[H]Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Shin N, et al. Abstract 2671: INCB050465, a novel PI3Kδ inhibitor, synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. Cancer Research. 2015, Aug. 75(15)

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